a tool for identifying drug-targetable redox-active disulphides

DNA polymerase subunit gamma-2, mitochondrial

Intermolecular

Cysteine 548 of DNA polymerase subunit gamma-1 and cysteine 399

A redox-regulated disulphide may form between cysteine 548 of DNA polymerase subunit gamma-1 and cysteine 399 of DNA polymerase subunit gamma-2, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

structural basis for processivity and antiviral drug toxicity in human mitochondrial dna replicase

Structure deposition date

2015-05-15

Thiol separation (Å)

10

Half-sphere exposure sum ?

61

Minimum pK_a ?

10

% buried

57

Peptide A name

DNA polymerase subunit gamma-1

Peptide B name

DNA polymerase subunit gamma-2, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

548

Peptide B residue number

399

Ligandability

Cysteine 548 of DNA polymerase subunit gamma-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 399 of DNA polymerase subunit gamma-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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