ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin carboxyl-terminal hydrolase 25

Intermolecular
Cysteine 551 and cysteine 551
A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 25 at cysteines 551 and 551. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6hel
Structure name
structure of human usp25
Structure deposition date
2018-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
60
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 25
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 25
Peptide A accession
Q9UHP3
Peptide B accession
Q9UHP3
Peptide A residue number
551
Peptide B residue number
551

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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