ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Zinc finger HIT domain-containing protein 2

Intramolecular
Cysteine 7 and cysteine 10
Cysteine 7 and cysteine 34
Cysteine 22 and cysteine 25
Cysteine 7 and cysteine 30
Cysteine 22 and cysteine 41
Cysteine 10 and cysteine 30
Cysteine 30 and cysteine 34
Cysteine 10 and cysteine 34
Cysteine 25 and cysteine 41
A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 7 and 10 (14 and 17 respectively in this structure).

Details

Redox score ?
90
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
0
Peptide accession
Q9UHR6
Residue number A
7
Residue number B
10
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 7 of Zinc finger HIT domain-containing protein 2

Cysteine 10 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 7 and 34 (14 and 41 respectively in this structure).

Details

Redox score ?
89
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
0
Peptide accession
Q9UHR6
Residue number A
7
Residue number B
34
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 7 of Zinc finger HIT domain-containing protein 2

Cysteine 34 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 22 and 25 (29 and 32 respectively in this structure).

Details

Redox score ?
88
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
0
Peptide accession
Q9UHR6
Residue number A
22
Residue number B
25
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 22 of Zinc finger HIT domain-containing protein 2

Cysteine 25 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 7 and 30 (14 and 37 respectively in this structure).

Details

Redox score ?
87
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
0
Peptide accession
Q9UHR6
Residue number A
7
Residue number B
30
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 7 of Zinc finger HIT domain-containing protein 2

Cysteine 30 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 22 and 41 (29 and 48 respectively in this structure).

Details

Redox score ?
87
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
0
Peptide accession
Q9UHR6
Residue number A
22
Residue number B
41
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 22 of Zinc finger HIT domain-containing protein 2

Cysteine 41 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 10 and 30 (17 and 37 respectively in this structure).

Details

Redox score ?
84
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UHR6
Residue number A
10
Residue number B
30
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 10 of Zinc finger HIT domain-containing protein 2

Cysteine 30 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 30 and 34 (37 and 41 respectively in this structure).

Details

Redox score ?
81
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UHR6
Residue number A
30
Residue number B
34
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 30 of Zinc finger HIT domain-containing protein 2

Cysteine 34 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 10 and 34 (17 and 41 respectively in this structure).

Details

Redox score ?
80
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
11
% buried
0
Peptide accession
Q9UHR6
Residue number A
10
Residue number B
34
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 10 of Zinc finger HIT domain-containing protein 2

Cysteine 34 of Zinc finger HIT domain-containing protein 2

A redox-regulated disulphide may form within Zinc finger HIT domain-containing protein 2 between cysteines 25 and 41 (32 and 48 respectively in this structure).

Details

Redox score ?
79
PDB code
1x4s
Structure name
solution structure of zinc finger hit domain in protein fon
Structure deposition date
2005-05-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UHR6
Residue number A
25
Residue number B
41
Peptide name
Zinc finger HIT domain-containing protein 2

Ligandability

Cysteine 25 of Zinc finger HIT domain-containing protein 2

Cysteine 41 of Zinc finger HIT domain-containing protein 2

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