ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galactoside-binding soluble lectin 13

Intramolecular
Cysteine 136 and cysteine 138
Cysteine 19 and cysteine 92
Cysteine 19 and cysteine 138
Cysteine 19 and cysteine 136
Cysteine 92 and cysteine 138
Cysteine 92 and cysteine 136
A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 136 and 138.

Details

Redox score ?
67
PDB code
6a65
Structure name
placental protein 13/galectin-13 variant r53hr55n with tris
Structure deposition date
2018-06-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UHV8
Residue number A
136
Residue number B
138
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 136 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 19 and 92 (22 and 95 respectively in this structure).

Details

Redox score ?
66
PDB code
6kjx
Structure name
galectin-13 variant c138s
Structure deposition date
2019-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
40
Peptide accession
Q9UHV8
Residue number A
19
Residue number B
92
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 19 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 19 and 138.

Details

Redox score ?
60
PDB code
6a63
Structure name
placental protein 13/galectin-13 variant r53hh57r with lactose
Structure deposition date
2018-06-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
16
Peptide accession
Q9UHV8
Residue number A
19
Residue number B
138
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 19 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 19 and 136 (22 and 139 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6kjx
Structure name
galectin-13 variant c138s
Structure deposition date
2019-07-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
26
Peptide accession
Q9UHV8
Residue number A
19
Residue number B
136
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 19 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 92 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6a65
Structure name
placental protein 13/galectin-13 variant r53hr55n with tris
Structure deposition date
2018-06-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
18
Peptide accession
Q9UHV8
Residue number A
92
Residue number B
138
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 92 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactoside-binding soluble lectin 13 between cysteines 92 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6a65
Structure name
placental protein 13/galectin-13 variant r53hr55n with tris
Structure deposition date
2018-06-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
18
Peptide accession
Q9UHV8
Residue number A
92
Residue number B
136
Peptide name
Galactoside-binding soluble lectin 13

Ligandability

Cysteine 92 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Galactoside-binding soluble lectin 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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