ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Translation initiation factor eIF-2B subunit delta

Intermolecular
Cysteine 198 of Translation initiation factor eIF-2B subunit beta and cysteine 465
Cysteine 194 of Translation initiation factor eIF-2B subunit beta and cysteine 465
Intramolecular
Cysteine 438 and cysteine 444 L
Cysteine 437 and cysteine 438
Cysteine 438 and cysteine 509
A redox-regulated disulphide may form between cysteine 198 of Translation initiation factor eIF-2B subunit beta and cysteine 465 of Translation initiation factor eIF-2B subunit delta.

Details

Redox score ?
86
PDB code
7kmf
Structure name
sugar phosphate activation of the stress sensor eif2b
Structure deposition date
2020-11-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
4
% buried
66
Peptide A name
Translation initiation factor eIF-2B subunit beta
Peptide B name
Translation initiation factor eIF-2B subunit delta
Peptide A accession
P49770
Peptide B accession
Q9UI10
Peptide A residue number
198
Peptide B residue number
465

Ligandability

Cysteine 198 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 465 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 194 of Translation initiation factor eIF-2B subunit beta and cysteine 465 of Translation initiation factor eIF-2B subunit delta. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7kmf
Structure name
sugar phosphate activation of the stress sensor eif2b
Structure deposition date
2020-11-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
4
% buried
74
Peptide A name
Translation initiation factor eIF-2B subunit beta
Peptide B name
Translation initiation factor eIF-2B subunit delta
Peptide A accession
P49770
Peptide B accession
Q9UI10
Peptide A residue number
194
Peptide B residue number
465

Ligandability

Cysteine 194 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 465 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit delta between cysteines 438 and 444. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7f66
Structure name
eif2b-sfsv nss-1-eif2
Structure deposition date
2021-06-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
92
Peptide accession
Q9UI10
Residue number A
438
Residue number B
444
Peptide name
Translation initiation factor eIF-2B subunit delta

Ligandability

Cysteine 438 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit delta between cysteines 437 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7rlo
Structure name
structure of the human eukaryotic translation initiation factor 2b (eif2b) in complex with a viral protein nss
Structure deposition date
2021-07-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
97
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UI10
Residue number A
437
Residue number B
438
Peptide name
Translation initiation factor eIF-2B subunit delta

Ligandability

Cysteine 437 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 438 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit delta between cysteines 438 and 509. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
7d46
Structure name
eif2b apo
Structure deposition date
2020-09-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
99
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UI10
Residue number A
438
Residue number B
509
Peptide name
Translation initiation factor eIF-2B subunit delta

Ligandability

Cysteine 438 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 509 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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