a tool for identifying drug-targetable redox-active disulphides

Carboxypeptidase A4

Intramolecular

Cysteine 250 and cysteine 273

A redox-regulated disulphide may form within Carboxypeptidase A4 between cysteines 250 and 273 (138 and 161 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

human carboxypeptidase a4 in complex with human latexin

Structure deposition date

2005-04-08

Thiol separation (Å)

2

Half-sphere exposure sum ?

51

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

250

Residue number B

273

Peptide name

Carboxypeptidase A4

Ligandability

Cysteine 250 of Carboxypeptidase A4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Carboxypeptidase A4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: