ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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rRNA methyltransferase 2, mitochondrial

Intramolecular
Cysteine 174 and cysteine 193
Cysteine 79 and cysteine 174
A redox-regulated disulphide may form within rRNA methyltransferase 2, mitochondrial between cysteines 174 and 193 (124 and 143 respectively in this structure).

Details

Redox score ?
69
PDB code
2nyu
Structure name
crystal structure of human ftsj homolog 2 (e
Structure deposition date
2006-11-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
8
% buried
100
Peptide accession
Q9UI43
Residue number A
174
Residue number B
193
Peptide name
rRNA methyltransferase 2, mitochondrial

Ligandability

Cysteine 174 of rRNA methyltransferase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of rRNA methyltransferase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within rRNA methyltransferase 2, mitochondrial between cysteines 79 and 174 (29 and 124 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
2nyu
Structure name
crystal structure of human ftsj homolog 2 (e
Structure deposition date
2006-11-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
98
Peptide accession
Q9UI43
Residue number A
79
Residue number B
174
Peptide name
rRNA methyltransferase 2, mitochondrial

Ligandability

Cysteine 79 of rRNA methyltransferase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of rRNA methyltransferase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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