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Bromodomain adjacent to zinc finger domain protein 2B

Intermolecular
Cysteine 827 and cysteine 827
Intramolecular
Cysteine 1934 and cysteine 1937
Cysteine 1949 and cysteine 1952
Cysteine 1934 and cysteine 1960
Cysteine 1949 and cysteine 1978
Cysteine 1949 and cysteine 1975
Cysteine 1934 and cysteine 1956
Cysteine 1937 and cysteine 1960
Cysteine 1952 and cysteine 1978
Cysteine 1952 and cysteine 1975
More...
Cysteine 1975 and cysteine 1978
Cysteine 1956 and cysteine 1960
Cysteine 1937 and cysteine 1956
Cysteine 1956 and cysteine 1975
A redox-regulated disulphide may form between two units of Bromodomain adjacent to zinc finger domain protein 2B at cysteines 827 and 827.

Details

Redox score ?
81
PDB code
7win
Structure name
crystal structure of baz2b tam domain
Structure deposition date
2022-01-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bromodomain adjacent to zinc finger domain protein 2B
Peptide B name
Bromodomain adjacent to zinc finger domain protein 2B
Peptide A accession
Q9UIF8
Peptide B accession
Q9UIF8
Peptide A residue number
827
Peptide B residue number
827

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1934 and 1937.

Details

Redox score ?
88
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
5
% buried
13
Peptide accession
Q9UIF8
Residue number A
1934
Residue number B
1937
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1934 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1937 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1949 and 1952.

Details

Redox score ?
87
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
23
Peptide accession
Q9UIF8
Residue number A
1949
Residue number B
1952
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1949 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1952 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1934 and 1960.

Details

Redox score ?
87
PDB code
6fhq
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr 21
Structure deposition date
2018-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
18
Peptide accession
Q9UIF8
Residue number A
1934
Residue number B
1960
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1934 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1960 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1949 and 1978.

Details

Redox score ?
83
PDB code
6fhq
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr 21
Structure deposition date
2018-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
19
Peptide accession
Q9UIF8
Residue number A
1949
Residue number B
1978
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1949 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1978 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1949 and 1975.

Details

Redox score ?
80
PDB code
6fhq
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr 21
Structure deposition date
2018-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
40
Peptide accession
Q9UIF8
Residue number A
1949
Residue number B
1975
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1949 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1975 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1934 and 1956.

Details

Redox score ?
79
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
41
Peptide accession
Q9UIF8
Residue number A
1934
Residue number B
1956
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1934 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1956 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1937 and 1960.

Details

Redox score ?
78
PDB code
6fhq
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr 21
Structure deposition date
2018-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
6
Peptide accession
Q9UIF8
Residue number A
1937
Residue number B
1960
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1937 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1960 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1952 and 1978.

Details

Redox score ?
77
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
12
Peptide accession
Q9UIF8
Residue number A
1952
Residue number B
1978
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1952 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1978 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1952 and 1975.

Details

Redox score ?
77
PDB code
4qf3
Structure name
crystal structure of human baz2b phd zinc finger in the free form
Structure deposition date
2014-05-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
30
Peptide accession
Q9UIF8
Residue number A
1952
Residue number B
1975
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1952 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1975 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1975 and 1978.

Details

Redox score ?
71
PDB code
4qf3
Structure name
crystal structure of human baz2b phd zinc finger in the free form
Structure deposition date
2014-05-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
28
Peptide accession
Q9UIF8
Residue number A
1975
Residue number B
1978
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1975 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1978 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1956 and 1960. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
38
Peptide accession
Q9UIF8
Residue number A
1956
Residue number B
1960
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1956 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1960 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1937 and 1956. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6fi1
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr23
Structure deposition date
2018-01-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
30
Peptide accession
Q9UIF8
Residue number A
1937
Residue number B
1956
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1937 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1956 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bromodomain adjacent to zinc finger domain protein 2B between cysteines 1956 and 1975. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6fhq
Structure name
crystal structure of human baz2b phd zinc finger in complex with fr 21
Structure deposition date
2018-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
54
Peptide accession
Q9UIF8
Residue number A
1956
Residue number B
1975
Peptide name
Bromodomain adjacent to zinc finger domain protein 2B

Ligandability

Cysteine 1956 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1975 of Bromodomain adjacent to zinc finger domain protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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