Methyl-CpG-binding domain protein 1
Intramolecular
Cysteine 191 and cysteine 194
Cysteine 179 and cysteine 215
Cysteine 191 and cysteine 210
Cysteine 194 and cysteine 210
Cysteine 179 and cysteine 182
Cysteine 188 and cysteine 194
Cysteine 188 and cysteine 210
Cysteine 176 and cysteine 179
Cysteine 341 and cysteine 344
Cysteine 176 and cysteine 215
More...Cysteine 182 and cysteine 215
Cysteine 188 and cysteine 191
Cysteine 338 and cysteine 341
Cysteine 176 and cysteine 182
Cysteine 341 and cysteine 377
Cysteine 350 and cysteine 353
Cysteine 353 and cysteine 356
Cysteine 338 and cysteine 377
Cysteine 350 and cysteine 372
Cysteine 344 and cysteine 377
Cysteine 356 and cysteine 372
Cysteine 353 and cysteine 372
Cysteine 338 and cysteine 344
Cysteine 350 and cysteine 356
Cysteine 194 and cysteine 208
Cysteine 8 and cysteine 57
Cysteine 353 and cysteine 357
Cysteine 356 and cysteine 357
Cysteine 350 and cysteine 357
Cysteine 208 and cysteine 210
Cysteine 357 and cysteine 372
4d4w A 30 A 33
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 191 and 194 (30 and 33 respectively in this structure).
Details
Redox score ?
87
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
191
Residue number B
194
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 191 of Methyl-CpG-binding domain protein 1
Cysteine 194 of Methyl-CpG-binding domain protein 1
4d4w A 18 A 54
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 179 and 215 (18 and 54 respectively in this structure).
Details
Redox score ?
86
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UIS9
Residue number A
179
Residue number B
215
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 179 of Methyl-CpG-binding domain protein 1
Cysteine 215 of Methyl-CpG-binding domain protein 1
4d4w A 30 A 49
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 191 and 210 (30 and 49 respectively in this structure).
Details
Redox score ?
86
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
191
Residue number B
210
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 191 of Methyl-CpG-binding domain protein 1
Cysteine 210 of Methyl-CpG-binding domain protein 1
4d4w A 33 A 49
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 194 and 210 (33 and 49 respectively in this structure).
Details
Redox score ?
85
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
194
Residue number B
210
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 194 of Methyl-CpG-binding domain protein 1
Cysteine 210 of Methyl-CpG-binding domain protein 1
4d4w A 18 A 21
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 179 and 182 (18 and 21 respectively in this structure).
Details
Redox score ?
84
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UIS9
Residue number A
179
Residue number B
182
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 179 of Methyl-CpG-binding domain protein 1
Cysteine 182 of Methyl-CpG-binding domain protein 1
4d4w A 27 A 33
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 188 and 194 (27 and 33 respectively in this structure).
Details
Redox score ?
84
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
188
Residue number B
194
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 188 of Methyl-CpG-binding domain protein 1
Cysteine 194 of Methyl-CpG-binding domain protein 1
4d4w A 27 A 49
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 188 and 210 (27 and 49 respectively in this structure).
Details
Redox score ?
83
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
188
Residue number B
210
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 188 of Methyl-CpG-binding domain protein 1
Cysteine 210 of Methyl-CpG-binding domain protein 1
4d4w A 15 A 18
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 176 and 179 (15 and 18 respectively in this structure).
Details
Redox score ?
83
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UIS9
Residue number A
176
Residue number B
179
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 176 of Methyl-CpG-binding domain protein 1
Cysteine 179 of Methyl-CpG-binding domain protein 1
5w9q B 341 B 344
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 341 and 344.
Details
Redox score ?
81
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
341
Residue number B
344
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 341 of Methyl-CpG-binding domain protein 1
Cysteine 344 of Methyl-CpG-binding domain protein 1
4d4w A 15 A 54
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 176 and 215 (15 and 54 respectively in this structure).
Details
Redox score ?
80
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UIS9
Residue number A
176
Residue number B
215
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 176 of Methyl-CpG-binding domain protein 1
Cysteine 215 of Methyl-CpG-binding domain protein 1
4d4w A 21 A 54
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 182 and 215 (21 and 54 respectively in this structure).
Details
Redox score ?
80
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UIS9
Residue number A
182
Residue number B
215
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 182 of Methyl-CpG-binding domain protein 1
Cysteine 215 of Methyl-CpG-binding domain protein 1
4d4w A 27 A 30
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 188 and 191 (27 and 30 respectively in this structure).
Details
Redox score ?
79
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
0
Peptide accession
Q9UIS9
Residue number A
188
Residue number B
191
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 188 of Methyl-CpG-binding domain protein 1
Cysteine 191 of Methyl-CpG-binding domain protein 1
5w9q B 338 B 341
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 338 and 341.
Details
Redox score ?
79
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
338
Residue number B
341
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 338 of Methyl-CpG-binding domain protein 1
Cysteine 341 of Methyl-CpG-binding domain protein 1
4d4w A 15 A 21
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 176 and 182 (15 and 21 respectively in this structure).
Details
Redox score ?
78
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UIS9
Residue number A
176
Residue number B
182
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 176 of Methyl-CpG-binding domain protein 1
Cysteine 182 of Methyl-CpG-binding domain protein 1
5w9q B 341 B 377
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 341 and 377.
Details
Redox score ?
76
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
341
Residue number B
377
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 341 of Methyl-CpG-binding domain protein 1
Cysteine 377 of Methyl-CpG-binding domain protein 1
5w9q A 350 A 353
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 350 and 353.
Details
Redox score ?
76
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
350
Residue number B
353
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 350 of Methyl-CpG-binding domain protein 1
Cysteine 353 of Methyl-CpG-binding domain protein 1
5w9q A 353 A 356
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 353 and 356.
Details
Redox score ?
76
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
353
Residue number B
356
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 353 of Methyl-CpG-binding domain protein 1
Cysteine 356 of Methyl-CpG-binding domain protein 1
5w9q B 338 B 377
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 338 and 377.
Details
Redox score ?
75
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
338
Residue number B
377
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 338 of Methyl-CpG-binding domain protein 1
Cysteine 377 of Methyl-CpG-binding domain protein 1
5w9q B 350 B 372
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 350 and 372.
Details
Redox score ?
75
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
350
Residue number B
372
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 350 of Methyl-CpG-binding domain protein 1
Cysteine 372 of Methyl-CpG-binding domain protein 1
5w9q A 344 A 377
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 344 and 377.
Details
Redox score ?
74
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
344
Residue number B
377
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 344 of Methyl-CpG-binding domain protein 1
Cysteine 377 of Methyl-CpG-binding domain protein 1
5w9q B 356 B 372
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 356 and 372.
Details
Redox score ?
74
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
356
Residue number B
372
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 356 of Methyl-CpG-binding domain protein 1
Cysteine 372 of Methyl-CpG-binding domain protein 1
5w9q B 353 B 372
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 353 and 372.
Details
Redox score ?
73
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
353
Residue number B
372
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 353 of Methyl-CpG-binding domain protein 1
Cysteine 372 of Methyl-CpG-binding domain protein 1
5w9q A 338 A 344
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 338 and 344.
Details
Redox score ?
73
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
338
Residue number B
344
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 338 of Methyl-CpG-binding domain protein 1
Cysteine 344 of Methyl-CpG-binding domain protein 1
5w9q A 350 A 356
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 350 and 356.
Details
Redox score ?
72
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
350
Residue number B
356
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 350 of Methyl-CpG-binding domain protein 1
Cysteine 356 of Methyl-CpG-binding domain protein 1
4d4w A 33 A 47
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 194 and 208 (33 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
194
Residue number B
208
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 194 of Methyl-CpG-binding domain protein 1
Cysteine 208 of Methyl-CpG-binding domain protein 1
1d9n A 8 A 57
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 8 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
1d9n
Structure name
solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional repressor mbd1/pcm1
Structure deposition date
1999-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
34
Peptide accession
Q9UIS9
Residue number A
8
Residue number B
57
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 8 of Methyl-CpG-binding domain protein 1
Cysteine 57 of Methyl-CpG-binding domain protein 1
5w9q A 353 A 357
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 353 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
353
Residue number B
357
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 353 of Methyl-CpG-binding domain protein 1
Cysteine 357 of Methyl-CpG-binding domain protein 1
5w9q A 356 A 357
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 356 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
356
Residue number B
357
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 356 of Methyl-CpG-binding domain protein 1
Cysteine 357 of Methyl-CpG-binding domain protein 1
5w9q B 350 B 357
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 350 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
350
Residue number B
357
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 350 of Methyl-CpG-binding domain protein 1
Cysteine 357 of Methyl-CpG-binding domain protein 1
4d4w A 47 A 49
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 208 and 210 (47 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4d4w
Structure name
solution structure of human mbd1 cxxc1 domain
Structure deposition date
2014-10-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
0
Peptide accession
Q9UIS9
Residue number A
208
Residue number B
210
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 208 of Methyl-CpG-binding domain protein 1
Cysteine 210 of Methyl-CpG-binding domain protein 1
5w9q A 357 A 372
A redox-regulated disulphide may form within Methyl-CpG-binding domain protein 1 between cysteines 357 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5w9q
Structure name
zinc finger region of mbd1 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UIS9
Residue number A
357
Residue number B
372
Peptide name
Methyl-CpG-binding domain protein 1
Ligandability
Cysteine 357 of Methyl-CpG-binding domain protein 1
Cysteine 372 of Methyl-CpG-binding domain protein 1
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