ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CCR4-NOT transcription complex subunit 7

Intermolecular
Cysteine 202 and cysteine 57 of Protein Tob1
Intramolecular
Cysteine 13 and cysteine 18
A redox-regulated disulphide may form between cysteine 202 of CCR4-NOT transcription complex subunit 7 and cysteine 57 of Protein Tob1 (202 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2d5r
Structure name
crystal structure of a tob-hcaf1 complex
Structure deposition date
2005-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide A name
CCR4-NOT transcription complex subunit 7
Peptide B name
Protein Tob1
Peptide A accession
Q9UIV1
Peptide B accession
P50616
Peptide A residue number
202
Peptide B residue number
57

Ligandability

Cysteine 202 of CCR4-NOT transcription complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Protein Tob1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 7 between cysteines 13 and 18. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4gmj
Structure name
structure of human not1 mif4g domain co-crystallized with caf1
Structure deposition date
2012-08-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
19
Peptide accession
Q9UIV1
Residue number A
13
Residue number B
18
Peptide name
CCR4-NOT transcription complex subunit 7

Ligandability

Cysteine 13 of CCR4-NOT transcription complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 18 of CCR4-NOT transcription complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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