ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RWD domain-containing protein 2A

Intramolecular
Cysteine 119 and cysteine 121
A redox-regulated disulphide may form within RWD domain-containing protein 2A between cysteines 119 and 121 (126 and 128 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2daw
Structure name
solution structure of the rwd domain of human rwd omain containing protein 2
Structure deposition date
2005-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
38
Peptide accession
Q9UIY3
Residue number A
119
Residue number B
121
Peptide name
RWD domain-containing protein 2A

Ligandability

Cysteine 119 of RWD domain-containing protein 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of RWD domain-containing protein 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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