ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rab5 GDP/GTP exchange factor

Intramolecular
Cysteine 19 and cysteine 38
Cysteine 35 and cysteine 38
Cysteine 19 and cysteine 23
Cysteine 19 and cysteine 35
Cysteine 23 and cysteine 35
Cysteine 23 and cysteine 38
Cysteine 360 and cysteine 361
Cysteine 290 and cysteine 294
A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 19 and 38.

Details

Redox score ?
86
PDB code
2fid
Structure name
crystal structure of a bovine rabex-5 fragment complexed with ubiquitin
Structure deposition date
2005-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
0
Peptide accession
O18973
Residue number A
19
Residue number B
38
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 19 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 35 and 38.

Details

Redox score ?
84
PDB code
2fif
Structure name
crystal structure of a bovine rabex-5 fragment complexed with ubiquitin
Structure deposition date
2005-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
0
Peptide accession
O18973
Residue number A
35
Residue number B
38
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 35 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 19 and 23.

Details

Redox score ?
84
PDB code
2fid
Structure name
crystal structure of a bovine rabex-5 fragment complexed with ubiquitin
Structure deposition date
2005-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide accession
O18973
Residue number A
19
Residue number B
23
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 19 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 19 and 35.

Details

Redox score ?
82
PDB code
2fif
Structure name
crystal structure of a bovine rabex-5 fragment complexed with ubiquitin
Structure deposition date
2005-12-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
0
Peptide accession
O18973
Residue number A
19
Residue number B
35
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 19 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 23 and 35.

Details

Redox score ?
79
PDB code
2c7n
Structure name
human rabex-5 residues 1-74 in complex with ubiquitin
Structure deposition date
2005-11-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
24
Peptide accession
Q53FG0
Residue number A
23
Residue number B
35
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 23 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 23 and 38.

Details

Redox score ?
77
PDB code
2c7n
Structure name
human rabex-5 residues 1-74 in complex with ubiquitin
Structure deposition date
2005-11-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
8
Peptide accession
Q53FG0
Residue number A
23
Residue number B
38
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 23 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 360 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4q9u
Structure name
crystal structure of the rab5, rabex-5delta and rabaptin-5c21 complex
Structure deposition date
2014-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
11
% buried
66
Peptide accession
Q9UJ41
Residue number A
360
Residue number B
361
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 360 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab5 GDP/GTP exchange factor between cysteines 290 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4q9u
Structure name
crystal structure of the rab5, rabex-5delta and rabaptin-5c21 complex
Structure deposition date
2014-05-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
86
Peptide accession
Q9UJ41
Residue number A
290
Residue number B
294
Peptide name
Rab5 GDP/GTP exchange factor

Ligandability

Cysteine 290 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of Rab5 GDP/GTP exchange factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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