ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Mitochondrial peptide methionine sulfoxide reductase

Intramolecular
Cysteine 72 and cysteine 218
Cysteine 72 and cysteine 107
A redox-regulated disulphide may form within Mitochondrial peptide methionine sulfoxide reductase between cysteines 72 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2l90
Structure name
solution structure of murine myristoylated msra
Structure deposition date
2011-01-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
50
Peptide accession
Q9D6Y7
Residue number A
72
Residue number B
218
Peptide name
Mitochondrial peptide methionine sulfoxide reductase

Ligandability

Cysteine 72 of Mitochondrial peptide methionine sulfoxide reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Mitochondrial peptide methionine sulfoxide reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial peptide methionine sulfoxide reductase between cysteines 72 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6agv
Structure name
crystal structure of apo mouse msra
Structure deposition date
2018-08-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
52
Peptide accession
Q9D6Y7
Residue number A
72
Residue number B
107
Peptide name
Mitochondrial peptide methionine sulfoxide reductase

Ligandability

Cysteine 72 of Mitochondrial peptide methionine sulfoxide reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Mitochondrial peptide methionine sulfoxide reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: