ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-type lectin domain family 4 member K

Intramolecular
Cysteine 223 and cysteine 319
Cysteine 295 and cysteine 311
A redox-regulated disulphide may form within C-type lectin domain family 4 member K between cysteines 223 and 319.

Details

Redox score ?
81
PDB code
3kqg
Structure name
trimeric structure of langerin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UJ71
Residue number A
223
Residue number B
319
Peptide name
C-type lectin domain family 4 member K

Ligandability

Cysteine 223 of C-type lectin domain family 4 member K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of C-type lectin domain family 4 member K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 4 member K between cysteines 295 and 311.

Details

Redox score ?
81
PDB code
3c22
Structure name
crystal structure of the carbohydrate recognition domain of human langerin
Structure deposition date
2008-01-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UJ71
Residue number A
295
Residue number B
311
Peptide name
C-type lectin domain family 4 member K

Ligandability

Cysteine 295 of C-type lectin domain family 4 member K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of C-type lectin domain family 4 member K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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