ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein Hook homolog 1

Intramolecular
Cysteine 127 and cysteine 131
Cysteine 15 and cysteine 31
A redox-regulated disulphide may form within Protein Hook homolog 1 between cysteines 127 and 131 (123 and 127 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1wix
Structure name
the solution structure of rsgi ruh-026, conserved domain of hook1 protein from mouse
Structure deposition date
2004-05-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
72
Peptide accession
Q8BIL5
Residue number A
127
Residue number B
131
Peptide name
Protein Hook homolog 1

Ligandability

Cysteine 127 of Protein Hook homolog 1

Cysteine 131 of Protein Hook homolog 1

A redox-regulated disulphide may form within Protein Hook homolog 1 between cysteines 15 and 31 (11 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1wix
Structure name
the solution structure of rsgi ruh-026, conserved domain of hook1 protein from mouse
Structure deposition date
2004-05-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
72
Peptide accession
Q8BIL5
Residue number A
15
Residue number B
31
Peptide name
Protein Hook homolog 1

Ligandability

Cysteine 15 of Protein Hook homolog 1

Cysteine 31 of Protein Hook homolog 1

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