ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Meteorin

Intermolecular
Cysteine 80 and cysteine 80
Cysteine 80 and cysteine 116
Cysteine 116 and cysteine 116
Intramolecular
Cysteine 169 and cysteine 240
Cysteine 28 and cysteine 49
Cysteine 172 and cysteine 264
Cysteine 182 and cysteine 286
A redox-regulated disulphide may form between two units of Meteorin at cysteines 80 and 80 (59 and 59 respectively in this structure).

Details

Redox score ?
69
PDB code
7tl6
Structure name
murine meteorin n-terminal cub domain
Structure deposition date
2022-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide A name
Meteorin
Peptide B name
Meteorin
Peptide A accession
Q8C1Q4
Peptide B accession
Q8C1Q4
Peptide A residue number
80
Peptide B residue number
80

Ligandability

A redox-regulated disulphide may form between two units of Meteorin at cysteines 80 and 116 (59 and 95 respectively in this structure).

Details

Redox score ?
68
PDB code
7tl6
Structure name
murine meteorin n-terminal cub domain
Structure deposition date
2022-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Meteorin
Peptide B name
Meteorin
Peptide A accession
Q8C1Q4
Peptide B accession
Q8C1Q4
Peptide A residue number
80
Peptide B residue number
116

Ligandability

Cysteine 80 of Meteorin

Cysteine 116 of Meteorin

A redox-regulated disulphide may form between two units of Meteorin at cysteines 116 and 116 (95 and 95 respectively in this structure).

Details

Redox score ?
64
PDB code
7tl6
Structure name
murine meteorin n-terminal cub domain
Structure deposition date
2022-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Meteorin
Peptide B name
Meteorin
Peptide A accession
Q8C1Q4
Peptide B accession
Q8C1Q4
Peptide A residue number
116
Peptide B residue number
116

Ligandability

A redox-regulated disulphide may form within Meteorin between cysteines 169 and 240 (148 and 219 respectively in this structure).

Details

Redox score ?
87
PDB code
7tlh
Structure name
murine meteorin c-terminal ntr domain
Structure deposition date
2022-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8C1Q4
Residue number A
169
Residue number B
240
Peptide name
Meteorin

Ligandability

Cysteine 169 of Meteorin

Cysteine 240 of Meteorin

A redox-regulated disulphide may form within Meteorin between cysteines 28 and 49 (7 and 28 respectively in this structure).

Details

Redox score ?
85
PDB code
7tl6
Structure name
murine meteorin n-terminal cub domain
Structure deposition date
2022-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8C1Q4
Residue number A
28
Residue number B
49
Peptide name
Meteorin

Ligandability

Cysteine 28 of Meteorin

Cysteine 49 of Meteorin

A redox-regulated disulphide may form within Meteorin between cysteines 172 and 264 (151 and 243 respectively in this structure).

Details

Redox score ?
84
PDB code
7tlh
Structure name
murine meteorin c-terminal ntr domain
Structure deposition date
2022-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8C1Q4
Residue number A
172
Residue number B
264
Peptide name
Meteorin

Ligandability

Cysteine 172 of Meteorin

Cysteine 264 of Meteorin

A redox-regulated disulphide may form within Meteorin between cysteines 182 and 286 (161 and 265 respectively in this structure).

Details

Redox score ?
83
PDB code
7tlh
Structure name
murine meteorin c-terminal ntr domain
Structure deposition date
2022-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8C1Q4
Residue number A
182
Residue number B
286
Peptide name
Meteorin

Ligandability

Cysteine 182 of Meteorin

Cysteine 286 of Meteorin

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