RNA pseudouridylate synthase domain-containing protein 1
Intramolecular
Cysteine 131 and cysteine 138
Cysteine 63 and cysteine 75
Cysteine 63 and cysteine 89
Cysteine 89 and cysteine 221
Cysteine 75 and cysteine 89
5vbb A 131 A 138
A redox-regulated disulphide may form within RNA pseudouridylate synthase domain-containing protein 1 between cysteines 131 and 138.
Details
Redox score ?
83
PDB code
5vbb
Structure name
human rna pseudouridylate synthase domain containing 1
Structure deposition date
2017-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UJJ7
Residue number A
131
Residue number B
138
Peptide name
RNA pseudouridylate synthase domain-containing protein 1
Ligandability
Cysteine 131 of RNA pseudouridylate synthase domain-containing protein 1
Cysteine 138 of RNA pseudouridylate synthase domain-containing protein 1
5vbb A 63 A 75
A redox-regulated disulphide may form within RNA pseudouridylate synthase domain-containing protein 1 between cysteines 63 and 75.
Details
Redox score ?
72
PDB code
5vbb
Structure name
human rna pseudouridylate synthase domain containing 1
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
77
Peptide accession
Q9UJJ7
Residue number A
63
Residue number B
75
Peptide name
RNA pseudouridylate synthase domain-containing protein 1
Ligandability
Cysteine 63 of RNA pseudouridylate synthase domain-containing protein 1
Cysteine 75 of RNA pseudouridylate synthase domain-containing protein 1
5vbb A 63 A 89
A redox-regulated disulphide may form within RNA pseudouridylate synthase domain-containing protein 1 between cysteines 63 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
5vbb
Structure name
human rna pseudouridylate synthase domain containing 1
Structure deposition date
2017-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
48
Peptide accession
Q9UJJ7
Residue number A
63
Residue number B
89
Peptide name
RNA pseudouridylate synthase domain-containing protein 1
Ligandability
Cysteine 63 of RNA pseudouridylate synthase domain-containing protein 1
Cysteine 89 of RNA pseudouridylate synthase domain-containing protein 1
5vbb A 89 A 221
A redox-regulated disulphide may form within RNA pseudouridylate synthase domain-containing protein 1 between cysteines 89 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5vbb
Structure name
human rna pseudouridylate synthase domain containing 1
Structure deposition date
2017-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
32
Peptide accession
Q9UJJ7
Residue number A
89
Residue number B
221
Peptide name
RNA pseudouridylate synthase domain-containing protein 1
Ligandability
Cysteine 89 of RNA pseudouridylate synthase domain-containing protein 1
Cysteine 221 of RNA pseudouridylate synthase domain-containing protein 1
5vbb A 75 A 89
A redox-regulated disulphide may form within RNA pseudouridylate synthase domain-containing protein 1 between cysteines 75 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5vbb
Structure name
human rna pseudouridylate synthase domain containing 1
Structure deposition date
2017-03-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
60
Peptide accession
Q9UJJ7
Residue number A
75
Residue number B
89
Peptide name
RNA pseudouridylate synthase domain-containing protein 1
Ligandability
Cysteine 75 of RNA pseudouridylate synthase domain-containing protein 1
Cysteine 89 of RNA pseudouridylate synthase domain-containing protein 1
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