Sal-like protein 4
Intermolecular
Cysteine 387 and cysteine 412
Cysteine 387 and cysteine 415
Intramolecular
Cysteine 882 and cysteine 885
Cysteine 412 and cysteine 415
Cysteine 910 and cysteine 913
Cysteine 881 and cysteine 882
Cysteine 881 and cysteine 885
7y3m C 387 A 412
A redox-regulated disulphide may form between two units of Sal-like protein 4 at cysteines 387 and 412. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7y3m
Structure name
structure of sall4 zfc1 bound with 16 bp at-rich dsdna
Structure deposition date
2022-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
32
Peptide A name
Sal-like protein 4
Peptide B name
Sal-like protein 4
Peptide A accession
Q9UJQ4
Peptide B accession
Q9UJQ4
Peptide A residue number
387
Peptide B residue number
412
Ligandability
Cysteine 387 of Sal-like protein 4
Cysteine 412 of Sal-like protein 4
7y3m C 387 A 415
A redox-regulated disulphide may form between two units of Sal-like protein 4 at cysteines 387 and 415. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7y3m
Structure name
structure of sall4 zfc1 bound with 16 bp at-rich dsdna
Structure deposition date
2022-06-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
10
% buried
32
Peptide A name
Sal-like protein 4
Peptide B name
Sal-like protein 4
Peptide A accession
Q9UJQ4
Peptide B accession
Q9UJQ4
Peptide A residue number
387
Peptide B residue number
415
Ligandability
Cysteine 387 of Sal-like protein 4
Cysteine 415 of Sal-like protein 4
8a4i J 882 J 885
A redox-regulated disulphide may form within Sal-like protein 4 between cysteines 882 and 885.
Details
Redox score ?
90
PDB code
8a4i
Structure name
crystal structure of sall4 zinc finger cluster 4 with at-rich dna
Structure deposition date
2022-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
0
Peptide accession
Q8BX22
Residue number A
882
Residue number B
885
Peptide name
Sal-like protein 4
Ligandability
Cysteine 882 of Sal-like protein 4
Cysteine 885 of Sal-like protein 4
6uml E 412 E 415
A redox-regulated disulphide may form within Sal-like protein 4 between cysteines 412 and 415.
Details
Redox score ?
88
PDB code
6uml
Structure name
structural basis for thalidomide teratogenicity revealed by the cereblon-ddb1-sall4-pomalidomide complex
Structure deposition date
2019-10-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
1
% buried
68
Peptide accession
Q9UJQ4
Residue number A
412
Residue number B
415
Peptide name
Sal-like protein 4
Ligandability
Cysteine 412 of Sal-like protein 4
Cysteine 415 of Sal-like protein 4
8a4i L 910 L 913
A redox-regulated disulphide may form within Sal-like protein 4 between cysteines 910 and 913.
Details
Redox score ?
83
PDB code
8a4i
Structure name
crystal structure of sall4 zinc finger cluster 4 with at-rich dna
Structure deposition date
2022-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
37
Peptide accession
Q8BX22
Residue number A
910
Residue number B
913
Peptide name
Sal-like protein 4
Ligandability
Cysteine 910 of Sal-like protein 4
Cysteine 913 of Sal-like protein 4
8a4i J 881 J 882
A redox-regulated disulphide may form within Sal-like protein 4 between cysteines 881 and 882. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
8a4i
Structure name
crystal structure of sall4 zinc finger cluster 4 with at-rich dna
Structure deposition date
2022-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
Q8BX22
Residue number A
881
Residue number B
882
Peptide name
Sal-like protein 4
Ligandability
Cysteine 881 of Sal-like protein 4
Cysteine 882 of Sal-like protein 4
8a4i I 881 I 885
A redox-regulated disulphide may form within Sal-like protein 4 between cysteines 881 and 885. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
8a4i
Structure name
crystal structure of sall4 zinc finger cluster 4 with at-rich dna
Structure deposition date
2022-06-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q8BX22
Residue number A
881
Residue number B
885
Peptide name
Sal-like protein 4
Ligandability
Cysteine 881 of Sal-like protein 4
Cysteine 885 of Sal-like protein 4
If this tool was useful for finding a disulphide, please cite: