Cell division cycle protein 23 homolog
Intramolecular
Cysteine 418 and cysteine 442
Cysteine 536 and cysteine 537
Cysteine 489 and cysteine 536
Cysteine 532 and cysteine 536
Cysteine 523 and cysteine 532
Cysteine 489 and cysteine 537
Cysteine 532 and cysteine 537
Cysteine 442 and cysteine 455
Cysteine 324 and cysteine 334
Cysteine 334 and cysteine 335
6tlj C 418 C 442
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 418 and 442.
Details
Redox score ?
68
PDB code
6tlj
Structure name
cryo-em structure of the anaphase-promoting complex/cyclosome, in complex with the mitotic checkpoint complex (apc/c-mcc) at 3
Structure deposition date
2019-12-02
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
100
Peptide accession
Q9UJX2
Residue number A
418
Residue number B
442
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 418 of Cell division cycle protein 23 homolog
Cysteine 442 of Cell division cycle protein 23 homolog
6q6g V 536 V 537
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 536 and 537. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6q6g
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d1 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
63
Peptide accession
Q9UJX2
Residue number A
536
Residue number B
537
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 536 of Cell division cycle protein 23 homolog
Cysteine 537 of Cell division cycle protein 23 homolog
6tnt P 489 P 536
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 489 and 536. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6tnt
Structure name
sumoylated apoapc/c with repositioned apc2 whb domain
Structure deposition date
2019-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
34
Peptide accession
Q9UJX2
Residue number A
489
Residue number B
536
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 489 of Cell division cycle protein 23 homolog
Cysteine 536 of Cell division cycle protein 23 homolog
6q6h V 532 V 536
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 532 and 536. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6q6h
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
48
Peptide accession
Q9UJX2
Residue number A
532
Residue number B
536
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 532 of Cell division cycle protein 23 homolog
Cysteine 536 of Cell division cycle protein 23 homolog
6q6h U 523 U 532
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 523 and 532. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6q6h
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
24
Peptide accession
Q9UJX2
Residue number A
523
Residue number B
532
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 523 of Cell division cycle protein 23 homolog
Cysteine 532 of Cell division cycle protein 23 homolog
6tnt P 489 P 537
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 489 and 537. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6tnt
Structure name
sumoylated apoapc/c with repositioned apc2 whb domain
Structure deposition date
2019-12-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
50
Peptide accession
Q9UJX2
Residue number A
489
Residue number B
537
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 489 of Cell division cycle protein 23 homolog
Cysteine 537 of Cell division cycle protein 23 homolog
7qe7 U 532 U 537
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 532 and 537. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
46
Peptide accession
Q9UJX2
Residue number A
532
Residue number B
537
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 532 of Cell division cycle protein 23 homolog
Cysteine 537 of Cell division cycle protein 23 homolog
5g04 C 442 C 455
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 442 and 455. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5g04
Structure name
structure of the human apc-cdc20-hsl1 complex
Structure deposition date
2016-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
100
Peptide accession
Q9UJX2
Residue number A
442
Residue number B
455
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 442 of Cell division cycle protein 23 homolog
Cysteine 455 of Cell division cycle protein 23 homolog
6tm5 P 324 P 334
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 324 and 334. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6tm5
Structure name
cryo-em structure of the anaphase-promoting complex/cyclosome, in complex with the nek2a substrate at 3
Structure deposition date
2019-12-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
98
Peptide accession
Q9UJX2
Residue number A
324
Residue number B
334
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 324 of Cell division cycle protein 23 homolog
Cysteine 334 of Cell division cycle protein 23 homolog
6tnt C 334 C 335
A redox-regulated disulphide may form within Cell division cycle protein 23 homolog between cysteines 334 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6tnt
Structure name
sumoylated apoapc/c with repositioned apc2 whb domain
Structure deposition date
2019-12-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UJX2
Residue number A
334
Residue number B
335
Peptide name
Cell division cycle protein 23 homolog
Ligandability
Cysteine 334 of Cell division cycle protein 23 homolog
Cysteine 335 of Cell division cycle protein 23 homolog
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