a tool for identifying drug-targetable redox-active disulphides

Anaphase-promoting complex subunit 7

Intramolecular

Cysteine 371 and cysteine 375

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 7 between cysteines 371 and 375 (405 and 409 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

structure of the human apc-cdh1-hsl1-ubch10 complex

Structure deposition date

2015-05-26

Thiol separation (Å)

8

Half-sphere exposure sum ?

61

Minimum pK_a ?

10

% buried

63

Peptide accession

Residue number A

371

Residue number B

375

Peptide name

Anaphase-promoting complex subunit 7

Ligandability

Cysteine 371 of Anaphase-promoting complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Anaphase-promoting complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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