ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anaphase-promoting complex subunit 5

Intramolecular
Cysteine 339 and cysteine 343
Cysteine 471 and cysteine 510
A redox-regulated disulphide may form within Anaphase-promoting complex subunit 5 between cysteines 339 and 343.

Details

Redox score ?
66
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
Q9UJX4
Residue number A
339
Residue number B
343
Peptide name
Anaphase-promoting complex subunit 5

Ligandability

Cysteine 339 of Anaphase-promoting complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Anaphase-promoting complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 5 between cysteines 471 and 510. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6q6h
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
94
Minimum pKa ?
9
% buried
100
Peptide accession
Q9UJX4
Residue number A
471
Residue number B
510
Peptide name
Anaphase-promoting complex subunit 5

Ligandability

Cysteine 471 of Anaphase-promoting complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Anaphase-promoting complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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