ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anaphase-promoting complex subunit 4

Intramolecular
Cysteine 599 and cysteine 697
Cysteine 112 and cysteine 205
Cysteine 70 and cysteine 112
Cysteine 271 and cysteine 273
Cysteine 599 and cysteine 638
Cysteine 70 and cysteine 205
Cysteine 112 and cysteine 209
A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 599 and 697. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
68
Peptide accession
Q9UJX5
Residue number A
599
Residue number B
697
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 599 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 697 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 112 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
94
Peptide accession
Q9UJX5
Residue number A
112
Residue number B
205
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 112 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 70 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UJX5
Residue number A
70
Residue number B
112
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 70 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 271 and 273. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
22
Peptide accession
Q9UJX5
Residue number A
271
Residue number B
273
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 271 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 599 and 638. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UJX5
Residue number A
599
Residue number B
638
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 599 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 638 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 70 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
5bpw
Structure name
atomic-resolution structures of the apc/c subunits apc4 and the apc5 n-terminal domain
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
94
Peptide accession
Q9UJX5
Residue number A
70
Residue number B
205
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 70 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 4 between cysteines 112 and 209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
6tnt
Structure name
sumoylated apoapc/c with repositioned apc2 whb domain
Structure deposition date
2019-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UJX5
Residue number A
112
Residue number B
209
Peptide name
Anaphase-promoting complex subunit 4

Ligandability

Cysteine 112 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Anaphase-promoting complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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