ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Anaphase-promoting complex subunit 2

Intramolecular
Cysteine 224 and cysteine 231
Cysteine 221 and cysteine 224 L
Cysteine 231 and cysteine 233 L
Cysteine 224 and cysteine 233 L
Cysteine 221 and cysteine 231 L
Cysteine 221 and cysteine 233 L
Cysteine 98 and cysteine 107
Cysteine 179 and cysteine 224
Cysteine 179 and cysteine 233 L
Cysteine 107 and cysteine 179
Cysteine 277 and cysteine 364
A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 224 and 231.

Details

Redox score ?
87
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
22
Peptide accession
Q9UJX6
Residue number A
224
Residue number B
231
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 224 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 221 and 224.

Details

Redox score ?
86
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
30
Peptide accession
Q9UJX6
Residue number A
221
Residue number B
224
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 221 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 231 and 233.

Details

Redox score ?
85
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
28
Peptide accession
Q9UJX6
Residue number A
231
Residue number B
233
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 231 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Anaphase-promoting complex subunit 2

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 224 and 233.

Details

Redox score ?
83
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
32
Peptide accession
Q9UJX6
Residue number A
224
Residue number B
233
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 224 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Anaphase-promoting complex subunit 2

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 221 and 231.

Details

Redox score ?
80
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
25
Peptide accession
Q9UJX6
Residue number A
221
Residue number B
231
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 221 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 221 and 233.

Details

Redox score ?
75
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
34
Peptide accession
Q9UJX6
Residue number A
221
Residue number B
233
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 221 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Anaphase-promoting complex subunit 2

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 98 and 107.

Details

Redox score ?
65
PDB code
6q6g
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d1 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
29
Peptide accession
Q9UJX6
Residue number A
98
Residue number B
107
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 98 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 179 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7qe7
Structure name
high-resolution structure of the anaphase-promoting complex/cyclosome (apc/c) bound to co-activator cdh1
Structure deposition date
2021-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
60
Peptide accession
Q9UJX6
Residue number A
179
Residue number B
224
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 179 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 179 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5g05
Structure name
cryo-em structure of combined apo phosphorylated apc
Structure deposition date
2016-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
32
Peptide accession
Q9UJX6
Residue number A
179
Residue number B
233
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 179 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Anaphase-promoting complex subunit 2

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 107 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6q6h
Structure name
cryo-em structure of the apc/c-cdc20-cdk2-cyclina2-cks2 complex, the d2 box class
Structure deposition date
2018-12-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
44
Peptide accession
Q9UJX6
Residue number A
107
Residue number B
179
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 107 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anaphase-promoting complex subunit 2 between cysteines 277 and 364. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4ui9
Structure name
atomic structure of the human anaphase-promoting complex
Structure deposition date
2015-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
80
Peptide accession
Q9UJX6
Residue number A
277
Residue number B
364
Peptide name
Anaphase-promoting complex subunit 2

Ligandability

Cysteine 277 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Anaphase-promoting complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: