ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ADP-ribosylation factor-binding protein GGA2

Intramolecular
Cysteine 50 and cysteine 89
Cysteine 89 and cysteine 93
Cysteine 50 and cysteine 93
A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA2 between cysteines 50 and 89.

Details

Redox score ?
82
PDB code
1mhq
Structure name
crystal structure of human gga2 vhs domain
Structure deposition date
2002-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UJY4
Residue number A
50
Residue number B
89
Peptide name
ADP-ribosylation factor-binding protein GGA2

Ligandability

Cysteine 50 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA2 between cysteines 89 and 93.

Details

Redox score ?
71
PDB code
1mhq
Structure name
crystal structure of human gga2 vhs domain
Structure deposition date
2002-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UJY4
Residue number A
89
Residue number B
93
Peptide name
ADP-ribosylation factor-binding protein GGA2

Ligandability

Cysteine 89 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA2 between cysteines 50 and 93.

Details

Redox score ?
66
PDB code
1mhq
Structure name
crystal structure of human gga2 vhs domain
Structure deposition date
2002-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9UJY4
Residue number A
50
Residue number B
93
Peptide name
ADP-ribosylation factor-binding protein GGA2

Ligandability

Cysteine 50 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of ADP-ribosylation factor-binding protein GGA2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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