ADP-ribosylation factor-binding protein GGA1
Intermolecular
Cysteine 77 and cysteine 77
Intramolecular
Cysteine 34 and cysteine 73
Cysteine 73 and cysteine 77
Cysteine 34 and cysteine 77
1ujj A 77 B 77
A redox-regulated disulphide may form between two units of ADP-ribosylation factor-binding protein GGA1 at cysteines 77 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1ujj
Structure name
vhs domain of human gga1 complexed with c-terminal peptide from bace
Structure deposition date
2003-08-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
54
Peptide A name
ADP-ribosylation factor-binding protein GGA1
Peptide B name
ADP-ribosylation factor-binding protein GGA1
Peptide A accession
Q9UJY5
Peptide B accession
Q9UJY5
Peptide A residue number
77
Peptide B residue number
77
Ligandability
1ujj B 34 B 73
A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA1 between cysteines 34 and 73.
Details
Redox score ?
82
PDB code
1ujj
Structure name
vhs domain of human gga1 complexed with c-terminal peptide from bace
Structure deposition date
2003-08-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UJY5
Residue number A
34
Residue number B
73
Peptide name
ADP-ribosylation factor-binding protein GGA1
Ligandability
Cysteine 34 of ADP-ribosylation factor-binding protein GGA1
Cysteine 73 of ADP-ribosylation factor-binding protein GGA1
3g2s B 73 B 77
A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA1 between cysteines 73 and 77.
Details
Redox score ?
72
PDB code
3g2s
Structure name
vhs domain of human gga1 complexed with sorla c-terminal peptide
Structure deposition date
2009-02-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UJY5
Residue number A
73
Residue number B
77
Peptide name
ADP-ribosylation factor-binding protein GGA1
Ligandability
Cysteine 73 of ADP-ribosylation factor-binding protein GGA1
Cysteine 77 of ADP-ribosylation factor-binding protein GGA1
1jwf A 34 A 77
A redox-regulated disulphide may form within ADP-ribosylation factor-binding protein GGA1 between cysteines 34 and 77.
Details
Redox score ?
67
PDB code
1jwf
Structure name
crystal structure of human gga1 vhs domain
Structure deposition date
2001-09-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9UJY5
Residue number A
34
Residue number B
77
Peptide name
ADP-ribosylation factor-binding protein GGA1
Ligandability
Cysteine 34 of ADP-ribosylation factor-binding protein GGA1
Cysteine 77 of ADP-ribosylation factor-binding protein GGA1
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