Potassium voltage-gated channel subfamily D member 3
Intermolecular
Cysteine 131 and cysteine 110
Cysteine 132 and cysteine 110
Cysteine 25 and cysteine 482
Cysteine 233 and cysteine 101 of Dipeptidylpeptidase 6
Cysteine 93 and cysteine 110
Intramolecular
Cysteine 131 and cysteine 132
Cysteine 207 and cysteine 218
Cysteine 93 and cysteine 132
Cysteine 93 and cysteine 131
Cysteine 228 and cysteine 233
1s1g A 131 B 110
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 3 at cysteines 131 and 110.
Details
Redox score ?
72
PDB code
1s1g
Structure name
crystal structure of kv4
Structure deposition date
2004-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
nan
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Potassium voltage-gated channel subfamily D member 3
Peptide A accession
Q9UK17
Peptide B accession
Q9UK17
Peptide A residue number
131
Peptide B residue number
110
Ligandability
Cysteine 131 of Potassium voltage-gated channel subfamily D member 3
Cysteine 110 of Potassium voltage-gated channel subfamily D member 3
1s1g A 132 B 110
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 3 at cysteines 132 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
1s1g
Structure name
crystal structure of kv4
Structure deposition date
2004-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
18
% buried
nan
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Potassium voltage-gated channel subfamily D member 3
Peptide A accession
Q9UK17
Peptide B accession
Q9UK17
Peptide A residue number
132
Peptide B residue number
110
Ligandability
Cysteine 132 of Potassium voltage-gated channel subfamily D member 3
Cysteine 110 of Potassium voltage-gated channel subfamily D member 3
7w6n B 25 H 482
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 3 at cysteines 25 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7w6n
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
48
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Potassium voltage-gated channel subfamily D member 3
Peptide A accession
Q9UK17
Peptide B accession
Q9UK17
Peptide A residue number
25
Peptide B residue number
482
Ligandability
Cysteine 25 of Potassium voltage-gated channel subfamily D member 3
Cysteine 482 of Potassium voltage-gated channel subfamily D member 3
7w6t B 233 I 46
A redox-regulated disulphide may form between cysteine 233 of Potassium voltage-gated channel subfamily D member 3 and cysteine 101 of Dipeptidylpeptidase 6 (233 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
46
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Dipeptidylpeptidase 6
Peptide A accession
Q9UK17
Peptide B accession
E9PWX1
Peptide A residue number
233
Peptide B residue number
101
Ligandability
Cysteine 233 of Potassium voltage-gated channel subfamily D member 3
Cysteine 101 of Dipeptidylpeptidase 6
1s1g A 93 B 110
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily D member 3 at cysteines 93 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
1s1g
Structure name
crystal structure of kv4
Structure deposition date
2004-01-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Potassium voltage-gated channel subfamily D member 3
Peptide A accession
Q9UK17
Peptide B accession
Q9UK17
Peptide A residue number
93
Peptide B residue number
110
Ligandability
Cysteine 93 of Potassium voltage-gated channel subfamily D member 3
Cysteine 110 of Potassium voltage-gated channel subfamily D member 3
2i2r C 131 C 132
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 3 between cysteines 131 and 132.
Details
Redox score ?
76
PDB code
2i2r
Structure name
crystal structure of the kchip1/kv4
Structure deposition date
2006-08-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
51
Peptide accession
Q62897
Residue number A
131
Residue number B
132
Peptide name
Potassium voltage-gated channel subfamily D member 3
Ligandability
Cysteine 131 of Potassium voltage-gated channel subfamily D member 3
Cysteine 132 of Potassium voltage-gated channel subfamily D member 3
7w6s H 207 H 218
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 3 between cysteines 207 and 218.
Details
Redox score ?
73
PDB code
7w6s
Structure name
cryoem structure of human kchip2-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UK17
Residue number A
207
Residue number B
218
Peptide name
Potassium voltage-gated channel subfamily D member 3
Ligandability
Cysteine 207 of Potassium voltage-gated channel subfamily D member 3
Cysteine 218 of Potassium voltage-gated channel subfamily D member 3
2nz0 B 93 B 132
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 3 between cysteines 93 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
2nz0
Structure name
crystal structure of potassium channel kv4
Structure deposition date
2006-11-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
90
Peptide accession
Q9UK17
Residue number A
93
Residue number B
132
Peptide name
Potassium voltage-gated channel subfamily D member 3
Ligandability
Cysteine 93 of Potassium voltage-gated channel subfamily D member 3
Cysteine 132 of Potassium voltage-gated channel subfamily D member 3
7w6t H 93 H 131
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 3 between cysteines 93 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
93
Peptide accession
Q9UK17
Residue number A
93
Residue number B
131
Peptide name
Potassium voltage-gated channel subfamily D member 3
Ligandability
Cysteine 93 of Potassium voltage-gated channel subfamily D member 3
Cysteine 131 of Potassium voltage-gated channel subfamily D member 3
7w6t B 228 B 233
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily D member 3 between cysteines 228 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
43
Peptide accession
Q9UK17
Residue number A
228
Residue number B
233
Peptide name
Potassium voltage-gated channel subfamily D member 3
Ligandability
Cysteine 228 of Potassium voltage-gated channel subfamily D member 3
Cysteine 233 of Potassium voltage-gated channel subfamily D member 3
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