ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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F-box only protein 2

Intramolecular
Cysteine 75 and cysteine 79 L
A redox-regulated disulphide may form within F-box only protein 2 between cysteines 75 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2e32
Structure name
structural basis for selection of glycosylated substrate by scffbs1 ubiquitin ligase
Structure deposition date
2006-11-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
76
Peptide accession
Q80UW2
Residue number A
75
Residue number B
79
Peptide name
F-box only protein 2

Ligandability

Cysteine 75 of F-box only protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 79 of F-box only protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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