Inhibitor of growth protein 1
Intramolecular
Cysteine 374 and cysteine 399
Cysteine 396 and cysteine 399
Cysteine 369 and cysteine 399
Cysteine 356 and cysteine 383
Cysteine 374 and cysteine 396
Cysteine 356 and cysteine 358
Cysteine 369 and cysteine 374
Cysteine 358 and cysteine 383
Cysteine 369 and cysteine 396
Cysteine 356 and cysteine 396
2qic A 231 A 256
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 374 and 399 (231 and 256 respectively in this structure).
Details
Redox score ?
88
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
6
Peptide accession
Q9UK53
Residue number A
374
Residue number B
399
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 374 of Inhibitor of growth protein 1
Cysteine 399 of Inhibitor of growth protein 1
2qic A 253 A 256
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 396 and 399 (253 and 256 respectively in this structure).
Details
Redox score ?
88
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
6
Peptide accession
Q9UK53
Residue number A
396
Residue number B
399
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 396 of Inhibitor of growth protein 1
Cysteine 399 of Inhibitor of growth protein 1
2qic A 226 A 256
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 369 and 399 (226 and 256 respectively in this structure).
Details
Redox score ?
86
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
8
Peptide accession
Q9UK53
Residue number A
369
Residue number B
399
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 369 of Inhibitor of growth protein 1
Cysteine 399 of Inhibitor of growth protein 1
2qic A 213 A 240
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 356 and 383 (213 and 240 respectively in this structure).
Details
Redox score ?
85
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
15
Peptide accession
Q9UK53
Residue number A
356
Residue number B
383
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 356 of Inhibitor of growth protein 1
Cysteine 383 of Inhibitor of growth protein 1
2qic A 231 A 253
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 374 and 396 (231 and 253 respectively in this structure).
Details
Redox score ?
85
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
13
Peptide accession
Q9UK53
Residue number A
374
Residue number B
396
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 374 of Inhibitor of growth protein 1
Cysteine 396 of Inhibitor of growth protein 1
2qic A 213 A 215
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 356 and 358 (213 and 215 respectively in this structure).
Details
Redox score ?
85
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
14
Peptide accession
Q9UK53
Residue number A
356
Residue number B
358
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 356 of Inhibitor of growth protein 1
Cysteine 358 of Inhibitor of growth protein 1
2qic A 226 A 231
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 369 and 374 (226 and 231 respectively in this structure).
Details
Redox score ?
83
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
14
Peptide accession
Q9UK53
Residue number A
369
Residue number B
374
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 369 of Inhibitor of growth protein 1
Cysteine 374 of Inhibitor of growth protein 1
2qic A 215 A 240
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 358 and 383 (215 and 240 respectively in this structure).
Details
Redox score ?
79
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
2
Peptide accession
Q9UK53
Residue number A
358
Residue number B
383
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 358 of Inhibitor of growth protein 1
Cysteine 383 of Inhibitor of growth protein 1
2qic A 226 A 253
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 369 and 396 (226 and 253 respectively in this structure).
Details
Redox score ?
78
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
14
Peptide accession
Q9UK53
Residue number A
369
Residue number B
396
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 369 of Inhibitor of growth protein 1
Cysteine 396 of Inhibitor of growth protein 1
2qic A 213 A 253
A redox-regulated disulphide may form within Inhibitor of growth protein 1 between cysteines 356 and 396 (213 and 253 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2qic
Structure name
crystal structure of the ing1 phd finger in complex with a histone h3k4me3 peptide
Structure deposition date
2007-07-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
20
Peptide accession
Q9UK53
Residue number A
356
Residue number B
396
Peptide name
Inhibitor of growth protein 1
Ligandability
Cysteine 356 of Inhibitor of growth protein 1
Cysteine 396 of Inhibitor of growth protein 1
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