F-box/LRR-repeat protein 5
Intermolecular
Cysteine 226 and cysteine 160 of S-phase kinase-associated protein 1 L
Intramolecular
Cysteine 676 and cysteine 686
Cysteine 662 and cysteine 687
Cysteine 686 and cysteine 687
Cysteine 681 and cysteine 686
Cysteine 393 and cysteine 608
Cysteine 662 and cysteine 686
Cysteine 676 and cysteine 687
Cysteine 608 and cysteine 636
Cysteine 676 and cysteine 681
More...Cysteine 381 and cysteine 382
Cysteine 226 and cysteine 228
Cysteine 355 and cysteine 382
Cysteine 662 and cysteine 676
Cysteine 636 and cysteine 676
Cysteine 636 and cysteine 662
6vcd B 226 C 160
A redox-regulated disulphide may form between cysteine 226 of F-box/LRR-repeat protein 5 and cysteine 160 of S-phase kinase-associated protein 1.
Details
Redox score ?
73
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
86
Peptide A name
F-box/LRR-repeat protein 5
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q9UKA1
Peptide B accession
P63208
Peptide A residue number
226
Peptide B residue number
160
Ligandability
Cysteine 226 of F-box/LRR-repeat protein 5
Cysteine 160 of S-phase kinase-associated protein 1
6vcd B 676 B 686
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 676 and 686.
Details
Redox score ?
75
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
7
% buried
82
Peptide accession
Q9UKA1
Residue number A
676
Residue number B
686
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 676 of F-box/LRR-repeat protein 5
Cysteine 686 of F-box/LRR-repeat protein 5
6vcd B 662 B 687
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 662 and 687.
Details
Redox score ?
70
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
8
% buried
71
Peptide accession
Q9UKA1
Residue number A
662
Residue number B
687
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 662 of F-box/LRR-repeat protein 5
Cysteine 687 of F-box/LRR-repeat protein 5
6vcd B 686 B 687
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 686 and 687.
Details
Redox score ?
67
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
69
Peptide accession
Q9UKA1
Residue number A
686
Residue number B
687
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 686 of F-box/LRR-repeat protein 5
Cysteine 687 of F-box/LRR-repeat protein 5
6vcd B 681 B 686
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 681 and 686. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
59
Peptide accession
Q9UKA1
Residue number A
681
Residue number B
686
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 681 of F-box/LRR-repeat protein 5
Cysteine 686 of F-box/LRR-repeat protein 5
6vcd B 393 B 608
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 393 and 608. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
96
Peptide accession
Q9UKA1
Residue number A
393
Residue number B
608
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 393 of F-box/LRR-repeat protein 5
Cysteine 608 of F-box/LRR-repeat protein 5
6vcd B 662 B 686
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 662 and 686. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
7
% buried
74
Peptide accession
Q9UKA1
Residue number A
662
Residue number B
686
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 662 of F-box/LRR-repeat protein 5
Cysteine 686 of F-box/LRR-repeat protein 5
6vcd B 676 B 687
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 676 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
79
Peptide accession
Q9UKA1
Residue number A
676
Residue number B
687
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 676 of F-box/LRR-repeat protein 5
Cysteine 687 of F-box/LRR-repeat protein 5
6vcd B 608 B 636
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 608 and 636. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UKA1
Residue number A
608
Residue number B
636
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 608 of F-box/LRR-repeat protein 5
Cysteine 636 of F-box/LRR-repeat protein 5
6vcd B 676 B 681
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 676 and 681. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
69
Peptide accession
Q9UKA1
Residue number A
676
Residue number B
681
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 676 of F-box/LRR-repeat protein 5
Cysteine 681 of F-box/LRR-repeat protein 5
6vcd B 381 B 382
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 381 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
55
Peptide accession
Q9UKA1
Residue number A
381
Residue number B
382
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 381 of F-box/LRR-repeat protein 5
Cysteine 382 of F-box/LRR-repeat protein 5
6vcd B 226 B 228
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 226 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
100
Peptide accession
Q9UKA1
Residue number A
226
Residue number B
228
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 226 of F-box/LRR-repeat protein 5
Cysteine 228 of F-box/LRR-repeat protein 5
6vcd B 355 B 382
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 355 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
90
Peptide accession
Q9UKA1
Residue number A
355
Residue number B
382
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 355 of F-box/LRR-repeat protein 5
Cysteine 382 of F-box/LRR-repeat protein 5
6vcd B 662 B 676
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 662 and 676. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
16
% buried
84
Peptide accession
Q9UKA1
Residue number A
662
Residue number B
676
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 662 of F-box/LRR-repeat protein 5
Cysteine 676 of F-box/LRR-repeat protein 5
6vcd B 636 B 676
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 636 and 676. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
96
Peptide accession
Q9UKA1
Residue number A
636
Residue number B
676
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 636 of F-box/LRR-repeat protein 5
Cysteine 676 of F-box/LRR-repeat protein 5
6vcd B 636 B 662
A redox-regulated disulphide may form within F-box/LRR-repeat protein 5 between cysteines 636 and 662. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6vcd
Structure name
cryo-em structure of irp2-fbxl5-skp1 complex
Structure deposition date
2019-12-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
88
Peptide accession
Q9UKA1
Residue number A
636
Residue number B
662
Peptide name
F-box/LRR-repeat protein 5
Ligandability
Cysteine 636 of F-box/LRR-repeat protein 5
Cysteine 662 of F-box/LRR-repeat protein 5
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