F-box/WD repeat-containing protein 11
Intermolecular
Cysteine 145 and cysteine 160 of S-phase kinase-associated protein 1 L
Intramolecular
Cysteine 235 and cysteine 272
Cysteine 408 and cysteine 448
Cysteine 245 and cysteine 285
Cysteine 285 and cysteine 336
6wnx G 32 H 142
A redox-regulated disulphide may form between cysteine 145 of F-box/WD repeat-containing protein 11 and cysteine 160 of S-phase kinase-associated protein 1 (32 and 142 respectively in this structure).
Details
Redox score ?
75
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
67
Peptide A name
F-box/WD repeat-containing protein 11
Peptide B name
S-phase kinase-associated protein 1
Peptide A accession
Q9UKB1
Peptide B accession
P63208
Peptide A residue number
145
Peptide B residue number
160
Ligandability
Cysteine 145 of F-box/WD repeat-containing protein 11
Cysteine 160 of S-phase kinase-associated protein 1
6wnx G 122 G 159
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 11 between cysteines 235 and 272 (122 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
58
Peptide accession
Q9UKB1
Residue number A
235
Residue number B
272
Peptide name
F-box/WD repeat-containing protein 11
Ligandability
Cysteine 235 of F-box/WD repeat-containing protein 11
Cysteine 272 of F-box/WD repeat-containing protein 11
6wnx G 295 G 335
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 11 between cysteines 408 and 448 (295 and 335 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UKB1
Residue number A
408
Residue number B
448
Peptide name
F-box/WD repeat-containing protein 11
Ligandability
Cysteine 408 of F-box/WD repeat-containing protein 11
Cysteine 448 of F-box/WD repeat-containing protein 11
6wnx G 132 G 172
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 11 between cysteines 245 and 285 (132 and 172 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
98
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UKB1
Residue number A
245
Residue number B
285
Peptide name
F-box/WD repeat-containing protein 11
Ligandability
Cysteine 245 of F-box/WD repeat-containing protein 11
Cysteine 285 of F-box/WD repeat-containing protein 11
6wnx A 172 A 223
A redox-regulated disulphide may form within F-box/WD repeat-containing protein 11 between cysteines 285 and 336 (172 and 223 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6wnx
Structure name
fbxw11-skp1 in complex with a pser33/pser37 beta-catenin peptide
Structure deposition date
2020-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
99
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UKB1
Residue number A
285
Residue number B
336
Peptide name
F-box/WD repeat-containing protein 11
Ligandability
Cysteine 285 of F-box/WD repeat-containing protein 11
Cysteine 336 of F-box/WD repeat-containing protein 11
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