ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cleavage and polyadenylation specificity factor subunit 3

Intramolecular
Cysteine 27 and cysteine 41
Cysteine 41 and cysteine 77
A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 3 between cysteines 27 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2i7v
Structure name
structure of human cpsf-73
Structure deposition date
2006-08-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q9UKF6
Residue number A
27
Residue number B
41
Peptide name
Cleavage and polyadenylation specificity factor subunit 3

Ligandability

Cysteine 27 of Cleavage and polyadenylation specificity factor subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Cleavage and polyadenylation specificity factor subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 3 between cysteines 41 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
6m8q
Structure name
cleavage and polyadenylation specificity factor subunit 3 (cpsf3) in complex with nvp-ltm531
Structure deposition date
2018-08-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UKF6
Residue number A
41
Residue number B
77
Peptide name
Cleavage and polyadenylation specificity factor subunit 3

Ligandability

Cysteine 41 of Cleavage and polyadenylation specificity factor subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Cleavage and polyadenylation specificity factor subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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