ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NTF2-related export protein 1

Intermolecular
Cysteine 492 of Nuclear RNA export factor 1 and cysteine 132
Intramolecular
Cysteine 14 and cysteine 77
A redox-regulated disulphide may form between cysteine 492 of Nuclear RNA export factor 1 and cysteine 132 of NTF2-related export protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4wyk
Structure name
structure of the lrr and ntf2-like domains of nxf1 complexed with nxt1
Structure deposition date
2014-11-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide A name
Nuclear RNA export factor 1
Peptide B name
NTF2-related export protein 1
Peptide A accession
Q9UBU9
Peptide B accession
Q9UKK6
Peptide A residue number
492
Peptide B residue number
132

Ligandability

Cysteine 492 of Nuclear RNA export factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of NTF2-related export protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NTF2-related export protein 1 between cysteines 14 and 77.

Details

Redox score ?
72
PDB code
4wyk
Structure name
structure of the lrr and ntf2-like domains of nxf1 complexed with nxt1
Structure deposition date
2014-11-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
7
% buried
96
Peptide accession
Q9UKK6
Residue number A
14
Residue number B
77
Peptide name
NTF2-related export protein 1

Ligandability

Cysteine 14 of NTF2-related export protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of NTF2-related export protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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