ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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PR domain zinc finger protein 4

Intramolecular
Cysteine 380 and cysteine 388
Cysteine 377 and cysteine 388
Cysteine 377 and cysteine 380
Cysteine 438 and cysteine 513
A redox-regulated disulphide may form within PR domain zinc finger protein 4 between cysteines 380 and 388.

Details

Redox score ?
87
PDB code
2l9z
Structure name
zinc knuckle in prdm4
Structure deposition date
2011-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UKN5
Residue number A
380
Residue number B
388
Peptide name
PR domain zinc finger protein 4

Ligandability

Cysteine 380 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PR domain zinc finger protein 4 between cysteines 377 and 388.

Details

Redox score ?
87
PDB code
2l9z
Structure name
zinc knuckle in prdm4
Structure deposition date
2011-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UKN5
Residue number A
377
Residue number B
388
Peptide name
PR domain zinc finger protein 4

Ligandability

Cysteine 377 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PR domain zinc finger protein 4 between cysteines 377 and 380.

Details

Redox score ?
80
PDB code
2l9z
Structure name
zinc knuckle in prdm4
Structure deposition date
2011-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q9UKN5
Residue number A
377
Residue number B
380
Peptide name
PR domain zinc finger protein 4

Ligandability

Cysteine 377 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PR domain zinc finger protein 4 between cysteines 438 and 513 (49 and 124 respectively in this structure).

Details

Redox score ?
67
PDB code
3db5
Structure name
crystal structure of methyltransferase domain of human pr domain- containing protein 4
Structure deposition date
2008-05-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
32
Peptide accession
Q9UKN5
Residue number A
438
Residue number B
513
Peptide name
PR domain zinc finger protein 4

Ligandability

Cysteine 438 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 513 of PR domain zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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