a tool for identifying drug-targetable redox-active disulphides

Zinc finger protein Helios

Intramolecular

Cysteine 142 and cysteine 145

A redox-regulated disulphide may form within Zinc finger protein Helios between cysteines 142 and 145.

Details

Redox score ?

64

PDB code

Structure name

crystal structure of ddb1-crbn-alv1 complex bound to helios (ikzf2 zf2)

Structure deposition date

2021-02-12

Thiol separation (Å)

4

Half-sphere exposure sum ?

70

Minimum pK_a ?

14

% buried

nan

Peptide accession

Residue number A

142

Residue number B

145

Peptide name

Zinc finger protein Helios

Ligandability

Cysteine 142 of Zinc finger protein Helios

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Zinc finger protein Helios

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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