F-box only protein 4

Intermolecular

Cysteine 160 of S-phase kinase-associated protein 1 and cysteine 80 L

Intramolecular

A redox-regulated disulphide may form between cysteine 160 of S-phase kinase-associated protein 1 and cysteine 80 of F-box only protein 4 (1160 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3l2o

Structure name

structure-based mechanism of dimerization-dependent ubiquitination by the scffbx4 ubiquitin ligase

Structure deposition date

2009-12-15

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

Peptide A name

S-phase kinase-associated protein 1

Peptide B name

F-box only protein 4

Peptide A accession

P63208

Peptide B accession

Q9UKT5

Peptide A residue number

160

Peptide B residue number

Ligandability

Cysteine 160 of S-phase kinase-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of F-box only protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-box only protein 4 between cysteines 146 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?