Protein argonaute-2
Intramolecular
Cysteine 455 and cysteine 462
Cysteine 455 and cysteine 492
Cysteine 462 and cysteine 492
Cysteine 272 and cysteine 344
Cysteine 490 and cysteine 492
Cysteine 327 and cysteine 344
Cysteine 717 and cysteine 751
Cysteine 751 and cysteine 787
3lud C 455 C 462
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 455 and 462.
Details
Redox score ?
68
PDB code
3lud
Structure name
crystal structure of mid domain from hago2 in complex with amp
Structure deposition date
2010-02-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
54
Peptide accession
Q9UKV8
Residue number A
455
Residue number B
462
Peptide name
Protein argonaute-2
Ligandability
Cysteine 455 of Protein argonaute-2
Cysteine 462 of Protein argonaute-2
6mfr A 455 A 492
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 455 and 492. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6mfr
Structure name
human argonaute2-mir-122 bound to a target rna with three central mismatches (bu3)
Structure deposition date
2018-09-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
53
Peptide accession
Q9UKV8
Residue number A
455
Residue number B
492
Peptide name
Protein argonaute-2
Ligandability
Cysteine 455 of Protein argonaute-2
Cysteine 492 of Protein argonaute-2
3luh A 462 A 492
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 462 and 492. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3luh
Structure name
crystal structure of mid domain from hago2 in complex with gmp
Structure deposition date
2010-02-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
81
Peptide accession
Q9UKV8
Residue number A
462
Residue number B
492
Peptide name
Protein argonaute-2
Ligandability
Cysteine 462 of Protein argonaute-2
Cysteine 492 of Protein argonaute-2
7ki3 A 272 A 344
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 272 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ki3
Structure name
human argonaute2:mir-122 bound to the hcv genotype 1a site-1 rna
Structure deposition date
2020-10-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UKV8
Residue number A
272
Residue number B
344
Peptide name
Protein argonaute-2
Ligandability
Cysteine 272 of Protein argonaute-2
Cysteine 344 of Protein argonaute-2
7ki3 A 490 A 492
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 490 and 492. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ki3
Structure name
human argonaute2:mir-122 bound to the hcv genotype 1a site-1 rna
Structure deposition date
2020-10-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9UKV8
Residue number A
490
Residue number B
492
Peptide name
Protein argonaute-2
Ligandability
Cysteine 490 of Protein argonaute-2
Cysteine 492 of Protein argonaute-2
6ra4 B 319 B 336
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 327 and 344 (319 and 336 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6ra4
Structure name
human argonaute-2 paz domain (214-347) in complex with cgugacucu
Structure deposition date
2019-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UKV8
Residue number A
327
Residue number B
344
Peptide name
Protein argonaute-2
Ligandability
Cysteine 327 of Protein argonaute-2
Cysteine 344 of Protein argonaute-2
4f3t A 717 A 751
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 717 and 751. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
4f3t
Structure name
human argonaute-2 - mir-20a complex
Structure deposition date
2012-05-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
81
Peptide accession
Q9UKV8
Residue number A
717
Residue number B
751
Peptide name
Protein argonaute-2
Ligandability
Cysteine 717 of Protein argonaute-2
Cysteine 751 of Protein argonaute-2
6mfn A 751 A 787
A redox-regulated disulphide may form within Protein argonaute-2 between cysteines 751 and 787. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
6mfn
Structure name
human argonaute2-mir-27a bound to hsur1 target rna
Structure deposition date
2018-09-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UKV8
Residue number A
751
Residue number B
787
Peptide name
Protein argonaute-2
Ligandability
Cysteine 751 of Protein argonaute-2
Cysteine 787 of Protein argonaute-2
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