ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guanine nucleotide exchange factor VAV3

Intramolecular
Cysteine 82 and cysteine 83
Cysteine 7 and cysteine 14
Cysteine 44 and cysteine 82
A redox-regulated disulphide may form within Guanine nucleotide exchange factor VAV3 between cysteines 82 and 83 (89 and 90 respectively in this structure).

Details

Redox score ?
60
PDB code
2d86
Structure name
solution structure of the ch domain from human vav-3 protein
Structure deposition date
2005-12-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
43
Peptide accession
Q9UKW4
Residue number A
82
Residue number B
83
Peptide name
Guanine nucleotide exchange factor VAV3

Ligandability

Cysteine 82 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor VAV3 between cysteines 7 and 14 (14 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2d86
Structure name
solution structure of the ch domain from human vav-3 protein
Structure deposition date
2005-12-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
80
Peptide accession
Q9UKW4
Residue number A
7
Residue number B
14
Peptide name
Guanine nucleotide exchange factor VAV3

Ligandability

Cysteine 7 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor VAV3 between cysteines 44 and 82 (51 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2d86
Structure name
solution structure of the ch domain from human vav-3 protein
Structure deposition date
2005-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
78
Peptide accession
Q9UKW4
Residue number A
44
Residue number B
82
Peptide name
Guanine nucleotide exchange factor VAV3

Ligandability

Cysteine 44 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Guanine nucleotide exchange factor VAV3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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