a tool for identifying drug-targetable redox-active disulphides

Nuclear pore complex protein Nup50

Intramolecular

Cysteine 416 and cysteine 428

A redox-regulated disulphide may form within Nuclear pore complex protein Nup50 between cysteines 416 and 428 (73 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

40

PDB code

Structure name

solution structure of the ranbd1 domain from human nucleoporin 50 kda

Structure deposition date

2007-02-09

Thiol separation (Å)

10

Half-sphere exposure sum ?

55

Minimum pK_a ?

9

% buried

41

Peptide accession

Residue number A

416

Residue number B

428

Peptide name

Nuclear pore complex protein Nup50

Ligandability

Cysteine 416 of Nuclear pore complex protein Nup50

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 428 of Nuclear pore complex protein Nup50

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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