ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc fingers and homeoboxes protein 1

Intramolecular
Cysteine 72 and cysteine 75
Cysteine 104 and cysteine 107
A redox-regulated disulphide may form within Zinc fingers and homeoboxes protein 1 between cysteines 72 and 75.

Details

Redox score ?
76
PDB code
2ghf
Structure name
solution structure of the complete zinc-finger region of human zinc- fingers and homeoboxes 1 (zhx1)
Structure deposition date
2006-03-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UKY1
Residue number A
72
Residue number B
75
Peptide name
Zinc fingers and homeoboxes protein 1

Ligandability

Cysteine 72 of Zinc fingers and homeoboxes protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Zinc fingers and homeoboxes protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc fingers and homeoboxes protein 1 between cysteines 104 and 107.

Details

Redox score ?
73
PDB code
2ghf
Structure name
solution structure of the complete zinc-finger region of human zinc- fingers and homeoboxes 1 (zhx1)
Structure deposition date
2006-03-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9UKY1
Residue number A
104
Residue number B
107
Peptide name
Zinc fingers and homeoboxes protein 1

Ligandability

Cysteine 104 of Zinc fingers and homeoboxes protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Zinc fingers and homeoboxes protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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