ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CCR4-NOT transcription complex subunit 11

Intermolecular
Cysteine 52 of CCR4-NOT transcription complex subunit 10 and cysteine 317
Intramolecular
Cysteine 453 and cysteine 478 L
Cysteine 432 and cysteine 436
Cysteine 436 and cysteine 453 L
A redox-regulated disulphide may form between cysteine 52 of CCR4-NOT transcription complex subunit 10 and cysteine 317 of CCR4-NOT transcription complex subunit 11.

Details

Redox score ?
69
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
26
Peptide A name
CCR4-NOT transcription complex subunit 10
Peptide B name
CCR4-NOT transcription complex subunit 11
Peptide A accession
Q9H9A5
Peptide B accession
Q9UKZ1
Peptide A residue number
52
Peptide B residue number
317

Ligandability

Cysteine 52 of CCR4-NOT transcription complex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 11 between cysteines 453 and 478.

Details

Redox score ?
67
PDB code
8bfj
Structure name
cnot11-ggnbp2 complex
Structure deposition date
2022-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
90
Peptide accession
Q9UKZ1
Residue number A
453
Residue number B
478
Peptide name
CCR4-NOT transcription complex subunit 11

Ligandability

Cysteine 453 of CCR4-NOT transcription complex subunit 11

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 11 between cysteines 432 and 436 (114 and 118 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
8bfh
Structure name
cnot11
Structure deposition date
2022-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
12
% buried
74
Peptide accession
Q9UKZ1
Residue number A
432
Residue number B
436
Peptide name
CCR4-NOT transcription complex subunit 11

Ligandability

Cysteine 432 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 436 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 11 between cysteines 436 and 453. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
8bfi
Structure name
human cnot1-cnot10-cnot11 module
Structure deposition date
2022-10-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
58
Peptide accession
Q9UKZ1
Residue number A
436
Residue number B
453
Peptide name
CCR4-NOT transcription complex subunit 11

Ligandability

Cysteine 436 of CCR4-NOT transcription complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of CCR4-NOT transcription complex subunit 11

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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