a tool for identifying drug-targetable redox-active disulphides

Dermatan-sulfate epimerase

Intramolecular

Cysteine 494 and cysteine 506

A redox-regulated disulphide may form within Dermatan-sulfate epimerase between cysteines 494 and 506.

Details

Redox score ?

81

PDB code

Structure name

crystal structure of human dermatan sulfate epimerase 1

Structure deposition date

2018-10-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

42

Minimum pK_a ?

8

% buried

10

Peptide accession

Residue number A

494

Residue number B

506

Peptide name

Dermatan-sulfate epimerase

Ligandability

Cysteine 494 of Dermatan-sulfate epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 506 of Dermatan-sulfate epimerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: