ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrator complex subunit 6

Intramolecular
Cysteine 314 and cysteine 347
Cysteine 311 and cysteine 314
Cysteine 311 and cysteine 347
A redox-regulated disulphide may form within Integrator complex subunit 6 between cysteines 314 and 347.

Details

Redox score ?
66
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
38
Peptide accession
Q9UL03
Residue number A
314
Residue number B
347
Peptide name
Integrator complex subunit 6

Ligandability

Cysteine 314 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 6 between cysteines 311 and 314. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
32
Peptide accession
Q9UL03
Residue number A
311
Residue number B
314
Peptide name
Integrator complex subunit 6

Ligandability

Cysteine 311 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 6 between cysteines 311 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
43
Peptide accession
Q9UL03
Residue number A
311
Residue number B
347
Peptide name
Integrator complex subunit 6

Ligandability

Cysteine 311 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Integrator complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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