Protein argonaute-1
Intramolecular
Cysteine 453 and cysteine 460
Cysteine 460 and cysteine 490
Cysteine 453 and cysteine 490
Cysteine 488 and cysteine 490
Cysteine 325 and cysteine 342
Cysteine 715 and cysteine 749
Cysteine 749 and cysteine 785
4krf A 453 A 460
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 453 and 460.
Details
Redox score ?
76
PDB code
4krf
Structure name
structure of human argonaute-1 let-7 complex
Structure deposition date
2013-05-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
56
Peptide accession
Q9UL18
Residue number A
453
Residue number B
460
Peptide name
Protein argonaute-1
Ligandability
Cysteine 453 of Protein argonaute-1
Cysteine 460 of Protein argonaute-1
5w6v A 460 A 490
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 460 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5w6v
Structure name
the structure of human argonaute-1 in complex with the hook motif of human gw182
Structure deposition date
2017-06-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
47
Peptide accession
Q9UL18
Residue number A
460
Residue number B
490
Peptide name
Protein argonaute-1
Ligandability
Cysteine 460 of Protein argonaute-1
Cysteine 490 of Protein argonaute-1
4kre A 453 A 490
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 453 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4kre
Structure name
structure of human argonaute-1 bound to endogenous sf9 rna
Structure deposition date
2013-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
62
Peptide accession
Q9UL18
Residue number A
453
Residue number B
490
Peptide name
Protein argonaute-1
Ligandability
Cysteine 453 of Protein argonaute-1
Cysteine 490 of Protein argonaute-1
5w6v A 488 A 490
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 488 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5w6v
Structure name
the structure of human argonaute-1 in complex with the hook motif of human gw182
Structure deposition date
2017-06-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
34
Peptide accession
Q9UL18
Residue number A
488
Residue number B
490
Peptide name
Protein argonaute-1
Ligandability
Cysteine 488 of Protein argonaute-1
Cysteine 490 of Protein argonaute-1
4kxt A 325 A 342
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 325 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
4kxt
Structure name
structure of human argonaute1 in complex with guide rna
Structure deposition date
2013-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
Q9UL18
Residue number A
325
Residue number B
342
Peptide name
Protein argonaute-1
Ligandability
Cysteine 325 of Protein argonaute-1
Cysteine 342 of Protein argonaute-1
4kre A 715 A 749
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 715 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
4kre
Structure name
structure of human argonaute-1 bound to endogenous sf9 rna
Structure deposition date
2013-05-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
79
Peptide accession
Q9UL18
Residue number A
715
Residue number B
749
Peptide name
Protein argonaute-1
Ligandability
Cysteine 715 of Protein argonaute-1
Cysteine 749 of Protein argonaute-1
5w6v A 749 A 785
A redox-regulated disulphide may form within Protein argonaute-1 between cysteines 749 and 785. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
5w6v
Structure name
the structure of human argonaute-1 in complex with the hook motif of human gw182
Structure deposition date
2017-06-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q9UL18
Residue number A
749
Residue number B
785
Peptide name
Protein argonaute-1
Ligandability
Cysteine 749 of Protein argonaute-1
Cysteine 785 of Protein argonaute-1
If this tool was useful for finding a disulphide, please cite: