ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related protein Rab-21

Intramolecular
Cysteine 126 and cysteine 128
Cysteine 126 and cysteine 177
Cysteine 128 and cysteine 177
A redox-regulated disulphide may form within Ras-related protein Rab-21 between cysteines 126 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2ot3
Structure name
crystal structure of rabex-5 vps9 domain in complex with nucleotide free rab21
Structure deposition date
2007-02-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
73
Peptide accession
Q9UL25
Residue number A
126
Residue number B
128
Peptide name
Ras-related protein Rab-21

Ligandability

Cysteine 126 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-related protein Rab-21 between cysteines 126 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2ot3
Structure name
crystal structure of rabex-5 vps9 domain in complex with nucleotide free rab21
Structure deposition date
2007-02-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
50
Peptide accession
Q9UL25
Residue number A
126
Residue number B
177
Peptide name
Ras-related protein Rab-21

Ligandability

Cysteine 126 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-related protein Rab-21 between cysteines 128 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
2ot3
Structure name
crystal structure of rabex-5 vps9 domain in complex with nucleotide free rab21
Structure deposition date
2007-02-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
76
Peptide accession
Q9UL25
Residue number A
128
Residue number B
177
Peptide name
Ras-related protein Rab-21

Ligandability

Cysteine 128 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Ras-related protein Rab-21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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