ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Short transient receptor potential channel 5

Intramolecular
Cysteine 176 and cysteine 178
Cysteine 176 and cysteine 181
Cysteine 178 and cysteine 181
Cysteine 553 and cysteine 558
A redox-regulated disulphide may form within Short transient receptor potential channel 5 between cysteines 176 and 178.

Details

Redox score ?
86
PDB code
7d4p
Structure name
structure of human trpc5 in complex with clemizole
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
7
% buried
0
Peptide accession
Q9UL62
Residue number A
176
Residue number B
178
Peptide name
Short transient receptor potential channel 5

Ligandability

Cysteine 176 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 5 between cysteines 176 and 181.

Details

Redox score ?
85
PDB code
7wdb
Structure name
human trpc5 channel in complex with riluzole
Structure deposition date
2021-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
8
Peptide accession
Q9UL62
Residue number A
176
Residue number B
181
Peptide name
Short transient receptor potential channel 5

Ligandability

Cysteine 176 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 5 between cysteines 178 and 181.

Details

Redox score ?
84
PDB code
7d4q
Structure name
structure of human trpc5 in complex with hc-070
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
7
Peptide accession
Q9UL62
Residue number A
178
Residue number B
181
Peptide name
Short transient receptor potential channel 5

Ligandability

Cysteine 178 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Short transient receptor potential channel 5 between cysteines 553 and 558.

Details

Redox score ?
84
PDB code
6aei
Structure name
cryo-em structure of the receptor-activated trpc5 ion channel
Structure deposition date
2018-08-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9QX29
Residue number A
553
Residue number B
558
Peptide name
Short transient receptor potential channel 5

Ligandability

Cysteine 553 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Short transient receptor potential channel 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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