ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger MIZ domain-containing protein 1

Intramolecular
Cysteine 39 and cysteine 81
Cysteine 39 and cysteine 56
Cysteine 81 and cysteine 100
Cysteine 56 and cysteine 81
Cysteine 17 and cysteine 56
A redox-regulated disulphide may form within Zinc finger MIZ domain-containing protein 1 between cysteines 39 and 81.

Details

Redox score ?
76
PDB code
5aiz
Structure name
the pias-like coactivator zmiz1 is a direct and selective cofactor of notch1 in t-cell development and leukemia
Structure deposition date
2015-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULJ6
Residue number A
39
Residue number B
81
Peptide name
Zinc finger MIZ domain-containing protein 1

Ligandability

Cysteine 39 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger MIZ domain-containing protein 1 between cysteines 39 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5aiz
Structure name
the pias-like coactivator zmiz1 is a direct and selective cofactor of notch1 in t-cell development and leukemia
Structure deposition date
2015-02-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULJ6
Residue number A
39
Residue number B
56
Peptide name
Zinc finger MIZ domain-containing protein 1

Ligandability

Cysteine 39 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger MIZ domain-containing protein 1 between cysteines 81 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5aiz
Structure name
the pias-like coactivator zmiz1 is a direct and selective cofactor of notch1 in t-cell development and leukemia
Structure deposition date
2015-02-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULJ6
Residue number A
81
Residue number B
100
Peptide name
Zinc finger MIZ domain-containing protein 1

Ligandability

Cysteine 81 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger MIZ domain-containing protein 1 between cysteines 56 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5aiz
Structure name
the pias-like coactivator zmiz1 is a direct and selective cofactor of notch1 in t-cell development and leukemia
Structure deposition date
2015-02-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULJ6
Residue number A
56
Residue number B
81
Peptide name
Zinc finger MIZ domain-containing protein 1

Ligandability

Cysteine 56 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger MIZ domain-containing protein 1 between cysteines 17 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5aiz
Structure name
the pias-like coactivator zmiz1 is a direct and selective cofactor of notch1 in t-cell development and leukemia
Structure deposition date
2015-02-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ULJ6
Residue number A
17
Residue number B
56
Peptide name
Zinc finger MIZ domain-containing protein 1

Ligandability

Cysteine 17 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Zinc finger MIZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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