Mediator of RNA polymerase II transcription subunit 23
Intramolecular
Cysteine 40 and cysteine 82 L
Cysteine 222 and cysteine 225 L
Cysteine 427 and cysteine 487
Cysteine 176 and cysteine 1295
Cysteine 284 and cysteine 297
Cysteine 791 and cysteine 868
6h02 A 40 A 82
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 40 and 82.
Details
Redox score ?
74
PDB code
6h02
Structure name
crystal structure of human mediator subunit med23
Structure deposition date
2018-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
65
Peptide accession
Q9ULK4
Residue number A
40
Residue number B
82
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 40 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 82 of Mediator of RNA polymerase II transcription subunit 23
6w1s R 222 R 225
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 222 and 225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
72
Peptide accession
Q80YQ2
Residue number A
222
Residue number B
225
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 222 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 225 of Mediator of RNA polymerase II transcription subunit 23
6w1s R 427 R 487
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 427 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
40
Peptide accession
Q80YQ2
Residue number A
427
Residue number B
487
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 427 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 487 of Mediator of RNA polymerase II transcription subunit 23
6h02 A 176 A 1295
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 176 and 1295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6h02
Structure name
crystal structure of human mediator subunit med23
Structure deposition date
2018-07-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
75
Peptide accession
Q9ULK4
Residue number A
176
Residue number B
1295
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 176 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 1295 of Mediator of RNA polymerase II transcription subunit 23
6h02 A 284 A 297
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 284 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6h02
Structure name
crystal structure of human mediator subunit med23
Structure deposition date
2018-07-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
71
Peptide accession
Q9ULK4
Residue number A
284
Residue number B
297
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 284 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 297 of Mediator of RNA polymerase II transcription subunit 23
6w1s R 791 R 868
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 23 between cysteines 791 and 868. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
100
Peptide accession
Q80YQ2
Residue number A
791
Residue number B
868
Peptide name
Mediator of RNA polymerase II transcription subunit 23
Ligandability
Cysteine 791 of Mediator of RNA polymerase II transcription subunit 23
Cysteine 868 of Mediator of RNA polymerase II transcription subunit 23
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