ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CCR4-NOT transcription complex subunit 6

Intramolecular
Cysteine 193 and cysteine 410
Cysteine 210 and cysteine 522
Cysteine 283 and cysteine 410
Cysteine 193 and cysteine 283
A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 6 between cysteines 193 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7ax1
Structure name
crystal structure of the human ccr4-caf1 complex
Structure deposition date
2020-11-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
100
Peptide accession
Q9ULM6
Residue number A
193
Residue number B
410
Peptide name
CCR4-NOT transcription complex subunit 6

Ligandability

Cysteine 193 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 6 between cysteines 210 and 522. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7ax1
Structure name
crystal structure of the human ccr4-caf1 complex
Structure deposition date
2020-11-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
82
Peptide accession
Q9ULM6
Residue number A
210
Residue number B
522
Peptide name
CCR4-NOT transcription complex subunit 6

Ligandability

Cysteine 210 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 522 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 6 between cysteines 283 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7ax1
Structure name
crystal structure of the human ccr4-caf1 complex
Structure deposition date
2020-11-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
12
% buried
100
Peptide accession
Q9ULM6
Residue number A
283
Residue number B
410
Peptide name
CCR4-NOT transcription complex subunit 6

Ligandability

Cysteine 283 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 6 between cysteines 193 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7ax1
Structure name
crystal structure of the human ccr4-caf1 complex
Structure deposition date
2020-11-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
13
% buried
100
Peptide accession
Q9ULM6
Residue number A
193
Residue number B
283
Peptide name
CCR4-NOT transcription complex subunit 6

Ligandability

Cysteine 193 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of CCR4-NOT transcription complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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