ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Two pore calcium channel protein 1

Intramolecular
Cysteine 598 and cysteine 599
Cysteine 213 and cysteine 216
A redox-regulated disulphide may form within Two pore calcium channel protein 1 between cysteines 598 and 599.

Details

Redox score ?
76
PDB code
6c96
Structure name
cryo-em structure of mouse tpc1 channel in the apo state
Structure deposition date
2018-01-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
36
Peptide accession
Q9EQJ0
Residue number A
598
Residue number B
599
Peptide name
Two pore calcium channel protein 1

Ligandability

Cysteine 598 of Two pore calcium channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 599 of Two pore calcium channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Two pore calcium channel protein 1 between cysteines 213 and 216.

Details

Redox score ?
65
PDB code
6c96
Structure name
cryo-em structure of mouse tpc1 channel in the apo state
Structure deposition date
2018-01-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
63
Peptide accession
Q9EQJ0
Residue number A
213
Residue number B
216
Peptide name
Two pore calcium channel protein 1

Ligandability

Cysteine 213 of Two pore calcium channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Two pore calcium channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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