a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase ZNRF3

Intramolecular

Cysteine 104 and cysteine 133

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZNRF3 between cysteines 104 and 133.

Details

Redox score ?

85

PDB code

Structure name

mouse znrf3 ectodomain crystal form ii

Structure deposition date

2013-09-30

Thiol separation (Å)

2

Half-sphere exposure sum ?

42

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

104

Residue number B

133

Peptide name

E3 ubiquitin-protein ligase ZNRF3

Ligandability

Cysteine 104 of E3 ubiquitin-protein ligase ZNRF3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of E3 ubiquitin-protein ligase ZNRF3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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